DTX3 and USP1

Data Source:
BioGRID (two hybrid)

		DTX3	USP1
Description		deltex E3 ubiquitin ligase 3	ubiquitin specific peptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity
	Biological Process	Notch Signaling Pathway Protein Ubiquitination	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage
Pathways			Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		44 interacting genes: ARF5 BAG3 DTX1 DTX2 EPM2AIP1 FAM90A1 FYN GRB2 MAPK9 NCK2 NFKBID NOTCH2 OSTF1 PARP11 PTK6 RNF141 RNF38 TCEANC TRAF4 TRIP10 UBASH3A UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2W UEVLD USP1 USP2 USP21 XIAP YES1 ZDHHC17 ZMYND19	15 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K
Entrez ID		196403	7398
HPRD ID		16842	04593
Ensembl ID		ENSG00000178498	ENSG00000162607
Uniprot IDs		A0A024RB96 Q8N9I9	O94782
PDB IDs			6DO5
Enriched GO Terms of Interacting Partners?
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