PHC2 and MAPKAPK2

Data Source:
HPRD (two hybrid, in vivo)

		PHC2	MAPKAPK2
Description		polyhomeotic homolog 2	MAPK activated protein kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Multicellular Organism Development Spermatogenesis Negative Regulation Of Transcription, DNA-templated	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Protein Phosphorylation Leukotriene Metabolic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of MRNA Stability Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Inner Ear Development 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs			Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
Diseases
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Blood protein levels ( 28240269) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		79 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417	42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1
Entrez ID		1912	9261
HPRD ID		10340	11882
Ensembl ID		ENSG00000134686	ENSG00000162889
Uniprot IDs		A0A0A0MSI2 Q8IXK0	P49137
PDB IDs			1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH 6TCA
Enriched GO Terms of Interacting Partners?
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