PHC2 and KRT31

Data Source:
BioGRID (two hybrid)

		PHC2	KRT31
Description		polyhomeotic homolog 2	keratin 31
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Multicellular Organism Development Spermatogenesis Negative Regulation Of Transcription, DNA-templated	Cytoskeleton Organization Epidermis Development Keratinization Cornification
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Brown vs. black hair color ( 30531825)
Interacting Genes		79 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417	356 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AKR7A3 ALDH3B1 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf109 C1orf216 C2CD6 C3 C5orf49 C5orf60 CA6 CARD9 CATIP CATSPER1 CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CDKN2C CDR2L CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CHCHD2 CHRNG CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DMRT3 DOCK2 DTNB EIF4E2 EIF4G1 ENKD1 EPDR1 EXOC8 EXOSC5 FADS2 FAM110A FAM124B FAM50B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MID2 MOS MRPL40 MSRB3 MTA1 MXD3 MXI1 MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 OTUB2 OTX1 P2RX7 P3H3 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PPP1R32 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPH PRR19 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RCOR3 RHPN1 RIBC1 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SHFL SHISA6 SIRPA SLC15A3 SLC23A1 SLC25A42 SLC25A6 SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TEX33 TFAP2D THAP7 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TYK2 UACA UBASH3A USHBP1 USP2 UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF688 ZNF69 ZNF835 ZNRF2P1
Entrez ID		1912	3881
HPRD ID		10340	03047
Ensembl ID		ENSG00000134686	ENSG00000094796
Uniprot IDs		A0A0A0MSI2 Q8IXK0	Q15323
PDB IDs
Enriched GO Terms of Interacting Partners?
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