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PHC2 and KRT31
Data Source:
BioGRID
(two hybrid)
PHC2
KRT31
Description
polyhomeotic homolog 2
keratin 31
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Extracellular Space
Cytosol
Intermediate Filament
Extracellular Exosome
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Biological Process
Multicellular Organism Development
Spermatogenesis
Negative Regulation Of Transcription, DNA-templated
Cytoskeleton Organization
Epidermis Development
Keratinization
Cornification
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Keratinization
Formation of the cornified envelope
Drugs
Diseases
GWAS
Adventurousness (
30643258
)
Blood urea nitrogen levels (
31152163
29403010
)
General risk tolerance (MTAG) (
30643258
)
Pulse pressure (
30224653
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
)
Brown vs. black hair color (
30531825
)
Interacting Genes
79 interacting genes:
AEN
AFG3L2
AP1M1
BMI1
BSDC1
BYSL
C1orf109
CARD9
CBX2
CRK
CRKL
CSNK2B
DRG1
ENKD1
FAM124A
FAM13C
FAM161A
FAM74A1
FAM74A4
FHL3
FOSB
GFI1B
GRB2
H3-4
HDAC7
KAT5
KBTBD7
KDM1A
KIFC3
KLHDC7B
KRT31
L3MBTL3
LMO1
LMO2
LMO3
MAB21L3
MAGEB6
MAPK14
MAPK6
MAPKAPK2
MCM2
MCRS1
MFAP1
MLLT6
MORF4L2
NCK1
PCGF2
PCGF3
PCGF5
PHC1
PLAGL2
PLK1
POLR2L
PPP1R16B
PRKAA1
PRPF3
PRPF31
RBM39
RNF2
RPL7
RWDD2B
SCMH1
SDCBP
SFMBT1
SIAH1
SMAD3
SPATC1L
SSX2IP
SYT16
TAB1
THAP7
TMEM70
TRIM41
TRIM55
TRIM63
ZBTB24
ZGPAT
ZMAT2
ZNF417
356 interacting genes:
A1CF
ABI2
ABI3
ABL1
ACTR10
AGR2
AGXT
AIMP2
AKR7A3
ALDH3B1
AMOT
AMOTL2
ANKRD36BP1
ANKS1A
AQP1
AQP5
ARHGAP35
ARID3A
ARMC7
ARSJ
ASMTL
ASPSCR1
ATG9A
ATN1
ATXN7L1
ATXN7L2
AVPI1
B4GALT7
BAD
BCAS2
BEX1
BEX2
BFSP2
BHLHA9
BRME1
BTC
BYSL
C19orf73
C1orf109
C1orf216
C2CD6
C3
C5orf49
C5orf60
CA6
CARD9
CATIP
CATSPER1
CBX8
CCDC112
CCDC116
CCDC120
CCDC146
CCDC17
CCDC187
CCDC196
CCDC198
CCDC93
CCER1
CCHCR1
CCNC
CD33
CDC20B
CDK18
CDKN1A
CDKN2C
CDR2L
CEP57
CEP57L1
CEP70
CFAP206
CFAP53
CHCHD2
CHRNG
CLCNKA
CLDN19
CLDN2
CLEC18A
CNNM3
CNTF
COA5
COMT
COX5A
COX5B
CRACR2A
CREB5
CRH
CTSG
CXCL16
CYSRT1
DEF6
DGCR6L
DHX37
DMRT3
DOCK2
DTNB
EIF4E2
EIF4G1
ENKD1
EPDR1
EXOC8
EXOSC5
FADS2
FAM110A
FAM124B
FAM50B
FAM71C
FAM74A4
FAM90A1
FARS2
FBF1
FBXW5
FGF16
FKBP1B
FOXB1
FRS3
GAD1
GADD45GIP1
GEM
GFAP
GFOD1
GLRX3
GNAI2
GNE
GNG10
GNG5
GOLGA6L2
GPS2
GSTP1
HAPLN2
HAUS1
HBA1
HBA2
HBZ
HCK
HDAC4
HGS
HNRNPLL
HOXA1
HOXB5
HS6ST1
HSD3B7
HSF4
HSPA12B
HSPD1
HYAL2
ICAM4
IL16
INPP5D
INPP5K
INSR
ITGB2
ITGB4
ITGB5
JOSD1
KCTD9
KDM1A
KIAA1217
KIFC3
KLC1
KLC4
KLHL38
KLK8
KRT1
KRT2
KRT20
KRT3
KRT4
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT72
KRT73
KRT74
KRT75
KRT76
KRT77
KRT78
KRT79
KRT8
KRT80
KRT81
KRT82
KRT83
KRT85
KRT86
KRTAP4-12
KRTAP5-6
KRTAP9-2
KRTAP9-3
LATS1
LCE1B
LCE3C
LCE3D
LCE3E
LCE4A
LENG1
LIF
LIN37
LINC00526
LMF2
LMNTD2
LMO3
LMO4
LONRF1
LRRC41
MAB21L2
MAP3K7CL
MAPKBP1
MARK4
MID2
MOS
MRPL40
MSRB3
MTA1
MXD3
MXI1
MYOM1
NAV1
NAXD
NEK6
NODAL
NPBWR2
NTAQ1
NUDT16L1
NUFIP2
OTUB2
OTX1
P2RX7
P3H3
PBX3
PDE4DIP
PDGFRB
PGAP6
PGLS
PHC2
PHLDA1
PIN1
PKN1
PKN3
PKP2
PLEKHN1
POLDIP3
POU4F2
POU4F3
PPP1R18
PPP1R32
PRF1
PRKAA2
PRKAB2
PRPF18
PRPF31
PRPH
PRR19
PRR35
PSMA1
PSMB1
PSMC5
PSMG2
PSPC1
PTGER3
PTPMT1
R3HDM2
RAB33A
RADIL
RAMAC
RCOR3
RHPN1
RIBC1
RPS19BP1
RPUSD3
RSPH14
RTP5
SAMD11
SCNM1
SEC14L4
SEMA4C
SHC3
SHFL
SHISA6
SIRPA
SLC15A3
SLC23A1
SLC25A42
SLC25A6
SMARCD1
SMARCE1
SMCP
SMG9
SNAI1
SNRNP25
SPATA24
SPG21
SPON2
SPRING1
SPRY1
SRSF2
SSX2IP
STK16
TACO1
TAPBPL
TCEANC
TEAD4
TEPSIN
TEX28
TEX33
TFAP2D
THAP7
TLE5
TMEM106C
TMEM174
TMEM231
TMSB4X
TRAF4
TRIML2
TROAP
TSEN54
TSG101
TSHZ3
TSNAX
TTC23
TTC9C
TXLNA
TYK2
UACA
UBASH3A
USHBP1
USP2
UTP23
UXT
VASN
VPS9D1
WDR25
WFDC6
ZDHHC1
ZFHX3
ZFYVE21
ZGPAT
ZIC1
ZNF124
ZNF148
ZNF20
ZNF250
ZNF414
ZNF417
ZNF446
ZNF564
ZNF569
ZNF572
ZNF587
ZNF688
ZNF69
ZNF835
ZNRF2P1
Entrez ID
1912
3881
HPRD ID
10340
03047
Ensembl ID
ENSG00000134686
ENSG00000094796
Uniprot IDs
A0A0A0MSI2
Q8IXK0
Q15323
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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