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PHC2 and FAM74A4
Data Source:
BioGRID
(two hybrid)
PHC2
FAM74A4
Description
polyhomeotic homolog 2
family with sequence similarity 74 member A4
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
Protein Binding
Biological Process
Multicellular Organism Development
Spermatogenesis
Negative Regulation Of Transcription, DNA-templated
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Drugs
Diseases
GWAS
Adventurousness (
30643258
)
Blood urea nitrogen levels (
31152163
29403010
)
General risk tolerance (MTAG) (
30643258
)
Pulse pressure (
30224653
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
)
Interacting Genes
79 interacting genes:
AEN
AFG3L2
AP1M1
BMI1
BSDC1
BYSL
C1orf109
CARD9
CBX2
CRK
CRKL
CSNK2B
DRG1
ENKD1
FAM124A
FAM13C
FAM161A
FAM74A1
FAM74A4
FHL3
FOSB
GFI1B
GRB2
H3-4
HDAC7
KAT5
KBTBD7
KDM1A
KIFC3
KLHDC7B
KRT31
L3MBTL3
LMO1
LMO2
LMO3
MAB21L3
MAGEB6
MAPK14
MAPK6
MAPKAPK2
MCM2
MCRS1
MFAP1
MLLT6
MORF4L2
NCK1
PCGF2
PCGF3
PCGF5
PHC1
PLAGL2
PLK1
POLR2L
PPP1R16B
PRKAA1
PRPF3
PRPF31
RBM39
RNF2
RPL7
RWDD2B
SCMH1
SDCBP
SFMBT1
SIAH1
SMAD3
SPATC1L
SSX2IP
SYT16
TAB1
THAP7
TMEM70
TRIM41
TRIM55
TRIM63
ZBTB24
ZGPAT
ZMAT2
ZNF417
26 interacting genes:
CCDC85B
CCNDBP1
CEP44
EFEMP2
EMG1
HMBOX1
IKZF1
KRT31
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-2
KRTAP5-9
LZTS2
MEOX2
MTUS2
NOTCH2NLA
PDE4DIP
PHC2
RPGRIP1
STX11
TCF4
TMCC2
Entrez ID
1912
401508
HPRD ID
10340
16982
Ensembl ID
ENSG00000134686
ENSG00000274583
Uniprot IDs
A0A0A0MSI2
Q8IXK0
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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