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PHC2 and PLK1
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
PHC2
PLK1
Description
polyhomeotic homolog 2
polo like kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Kinetochore
Chromatin
Synaptonemal Complex
Spindle Pole
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Spindle Microtubule
Microtubule Cytoskeleton
Midbody
Centriolar Satellite
Spindle Midzone
Mitotic Spindle Pole
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Anaphase-promoting Complex Binding
Kinase Activity
Protein Kinase Binding
Identical Protein Binding
Biological Process
Multicellular Organism Development
Spermatogenesis
Negative Regulation Of Transcription, DNA-templated
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Mitotic Cytokinesis
Microtubule Bundle Formation
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Sister Chromatid Cohesion
Mitotic Nuclear Envelope Disassembly
Mitotic Spindle Assembly Checkpoint
Centrosome Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Peptidyl-threonine Phosphorylation
Female Meiosis Chromosome Segregation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Negative Regulation Of Apoptotic Process
Regulation Of Protein Binding
Homologous Chromosome Segregation
Establishment Of Protein Localization
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Proteolysis
Nuclear Envelope Disassembly
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Synaptonemal Complex Disassembly
Protein Localization To Chromatin
Signal Transduction Involved In G2 DNA Damage Checkpoint
Protein Localization To Nuclear Envelope
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Protein Localization To Cell Cortex
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Drugs
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Wortmannin
Fostamatinib
Diseases
GWAS
Adventurousness (
30643258
)
Blood urea nitrogen levels (
31152163
29403010
)
General risk tolerance (MTAG) (
30643258
)
Pulse pressure (
30224653
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
79 interacting genes:
AEN
AFG3L2
AP1M1
BMI1
BSDC1
BYSL
C1orf109
CARD9
CBX2
CRK
CRKL
CSNK2B
DRG1
ENKD1
FAM124A
FAM13C
FAM161A
FAM74A1
FAM74A4
FHL3
FOSB
GFI1B
GRB2
H3-4
HDAC7
KAT5
KBTBD7
KDM1A
KIFC3
KLHDC7B
KRT31
L3MBTL3
LMO1
LMO2
LMO3
MAB21L3
MAGEB6
MAPK14
MAPK6
MAPKAPK2
MCM2
MCRS1
MFAP1
MLLT6
MORF4L2
NCK1
PCGF2
PCGF3
PCGF5
PHC1
PLAGL2
PLK1
POLR2L
PPP1R16B
PRKAA1
PRPF3
PRPF31
RBM39
RNF2
RPL7
RWDD2B
SCMH1
SDCBP
SFMBT1
SIAH1
SMAD3
SPATC1L
SSX2IP
SYT16
TAB1
THAP7
TMEM70
TRIM41
TRIM55
TRIM63
ZBTB24
ZGPAT
ZMAT2
ZNF417
120 interacting genes:
-
ACTL6B
APP
ASPM
BAG6
BCL2L1
BIRC6
BRCA2
BUB1
BUB1B
C6orf136
CCDC115
CCNB1
CDC14A
CDC25C
CENPQ
CEP55
CHEK2
CSN1S1
CSN2
CTNNB1
DNAJB9
DNHD1
ECT2
EIF6
FBXL5
FBXW7
FZR1
GET4
GLB1
GORASP1
IKBKB
INTS11
ITSN1
KIF23
KIF2C
KLF4
KLHL22
KRBA1
LMO4
LRP5L
LRRK1
LRRK2
MAD2L1BP
MAGED1
MCM2
MCM3
MCM7
MDM2
MPP2
MYC
MYT1
NEDD4
NHSL2
NINL
NPM1
NUDC
PARP10
PHC2
PIN1
PITPNM1
PKMYT1
PLK3
PPID
PRC1
PRKN
PSMA1
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PTEN
PTPRD
RABAC1
RACGAP1
RAD51
RAP1GAP
RECQL5
RELA
REST
RGCC
RICTOR
RNF126
RNF2
RXRA
SIMC1
SNCA
SNCB
SPOUT1
SREBF1
STAG2
STK3
STUB1
SUGT1
TANK
TNFSF11
TOP2A
TP53
TP53BP2
TP73
TPT1
TRIOBP
TSC1
TUBA4A
TUBB
TUBB3
TUBG1
USP16
USP7
VRK3
WEE1
ZNF71
Entrez ID
1912
5347
HPRD ID
10340
03652
Ensembl ID
ENSG00000134686
ENSG00000166851
Uniprot IDs
A0A0A0MSI2
Q8IXK0
P53350
PDB IDs
1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4O56
4O6W
4O9W
4RCP
4WHH
4WHK
4WHL
4X9R
4X9V
4X9W
5J19
5NEI
5NFU
5NJE
5NMM
5NN1
5NN2
5TA6
5TA8
6AX4
6GY2
Enriched GO Terms of Interacting Partners
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