CUX1 and BIN1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CUX1	BIN1
Description		cut like homeobox 1	bridging integrator 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Lipid Tube
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protease Binding Protein Binding Phospholipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Tau Protein Binding Actin Filament Binding Chaperone Binding RNA Polymerase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Dendrite Morphogenesis	Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Viral Process Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Nucleus Localization Lipid Tube Assembly Membrane Organization Regulation Of Cell Cycle Arrest Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic	Clathrin-mediated endocytosis
Drugs
Diseases			Centronuclear myopathy
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Basal cell carcinoma ( 31174203 27539887) Breast cancer ( 29059683) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Keratinocyte cancer (MTAG) ( 31174203) Mean platelet volume ( 32888494 27863252) Morning person ( 30696823) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to antidepressants ( 22584459) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alzheimer's disease ( 22832961 21460840 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 21390209 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis and Alzheimer's disease ( 22005930) Systemic lupus erythematosus ( 24871463)
Interacting Genes		21 interacting genes: BIN1 CA12 CCNA1 CDC25A CDK1 CDK7 CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4	46 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3
Entrez ID		1523	274
HPRD ID		00295	03150
Ensembl ID		ENSG00000257923	ENSG00000136717
Uniprot IDs		P39880 Q13948 Q3LIA3	A0A024RAE9 A0A024RAF0 A0A024RAF1 A0A024RAF6 A0A024RAG8 A0A024RAG9 A0A024RAI4 A0A024RAI5 A0A024RAI6 A0A024RAJ2 A0A024RAJ3 B7Z2Z2 B7Z6Y2 O00499 Q9BTH3
PDB IDs			1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?