BIN1 and ITGA1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BIN1	ITGA1
Description		bridging integrator 1	integrin subunit alpha 1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Lipid Tube	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Tau Protein Binding Actin Filament Binding Chaperone Binding RNA Polymerase Binding	Signaling Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Viral Process Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Nucleus Localization Lipid Tube Assembly Membrane Organization Regulation Of Cell Cycle Arrest Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Activation Of MAPK Activity Muscle Contraction Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Extracellular Matrix Organization Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis
Pathways		Clathrin-mediated endocytosis	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen
Drugs
Diseases		Centronuclear myopathy
GWAS		Alzheimer's disease ( 22832961 21460840 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 21390209 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Family history of Alzheimer's disease ( 30617256) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 25188341) Neutrophil count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis and Alzheimer's disease ( 22005930) Systemic lupus erythematosus ( 24871463)	Acne (severe) ( 24927181) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein B levels ( 32203549) Attention deficit hyperactivity disorder ( 28809852) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 26708285) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Myocardial infarction ( 26708285) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum thyroid-stimulating hormone levels ( 25436638) Serum total protein level ( 29403010) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969 30130595 32499647 30718926 29926116)
Interacting Genes		46 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3	10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1
Entrez ID		274	3672
HPRD ID		03150	01892
Ensembl ID		ENSG00000136717	ENSG00000213949
Uniprot IDs		A0A024RAE9 A0A024RAF0 A0A024RAF1 A0A024RAF6 A0A024RAG8 A0A024RAG9 A0A024RAI4 A0A024RAI5 A0A024RAI6 A0A024RAJ2 A0A024RAJ3 B7Z2Z2 B7Z6Y2 O00499 Q9BTH3	P56199
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22	1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ
Enriched GO Terms of Interacting Partners?
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