CUX1 and TLE4

Data Source:
BioGRID (pull down)

		CUX1	TLE4
Description		cut like homeobox 1	TLE family member 4, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Dendrite Morphogenesis	Biological_process Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Basal cell carcinoma ( 31174203 27539887) Breast cancer ( 29059683) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Keratinocyte cancer (MTAG) ( 31174203) Mean platelet volume ( 32888494 27863252) Morning person ( 30696823) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to antidepressants ( 22584459) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Asthma (childhood onset) ( 19714205) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Motion sickness ( 25628336) Neutrophil percentage of white cells ( 32888494) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 22885922 24509480 30297969 26818947 32499647 30718926 28869590)
Interacting Genes		21 interacting genes: BIN1 CA12 CCNA1 CDC25A CDK1 CDK7 CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4	10 interacting genes: BRCA1 CUX1 LIG4 MSX1 NUP62 OTX1 OTX2 PAX5 POU2F1 SRPK2
Entrez ID		1523	7091
HPRD ID		00295	05502
Ensembl ID		ENSG00000257923	ENSG00000106829
Uniprot IDs		P39880 Q13948 Q3LIA3	Q04727
PDB IDs
Enriched GO Terms of Interacting Partners?
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