L3MBTL2 and ZBTB48

Data Source:
BioGRID (two hybrid)

		L3MBTL2	ZBTB48
Description		L3MBTL histone methyl-lysine binding protein 2	zinc finger and BTB domain containing 48
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromosome, Telomeric Region Nucleus
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Double-stranded Telomeric DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Transcription, DNA-templated
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Body size at age 10 ( 32376654)
Interacting Genes		49 interacting genes: AMOTL2 BEND7 BHLHB9 BIVM CARD9 CCDC106 CCDC33 CEP76 EFHC2 EIF4ENIF1 FAM217B GAS8 GKAP1 GOLGA2 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829	33 interacting genes: C11orf58 CDK2AP2 CDKN1A CEP70 DVL2 DVL3 EP300 GPATCH2L ILK KRTAP1-1 KRTAP10-5 KRTAP10-7 L3MBTL2 LLCFC1 MCC NME7 PNRC2 RGS2 SPANXN2 THAP1 TNFRSF14 TRIM41 TSPYL2 UPF2 WDR5 ZBTB26 ZBTB6 ZBTB7A ZBTB8A ZBTB9 ZNF317 ZNF408 ZNF837
Entrez ID		83746	3104
HPRD ID		13954	01316
Ensembl ID		ENSG00000100395	ENSG00000204859
Uniprot IDs		A0A0S2Z5X6 Q969R5	A8K291 B2R702 P10074
PDB IDs		2W0T 3CEY 3F70	3B84 5YJ3
Enriched GO Terms of Interacting Partners?
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