CCR1 and TPST2

Data Source:
HPRD (in vitro)

		CCR1	TPST2
Description		C-C motif chemokine receptor 1	tyrosylprotein sulfotransferase 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	Peptidyl-tyrosine Sulfation Protein Phosphopantetheinylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)	Anti-saccade response ( 29064472) Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483)
Interacting Genes		29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	5 interacting genes: CCR1 CCR8 CMKLR1 GPR1 SELPLG
Entrez ID		1230	8459
HPRD ID		03101	07217
Ensembl ID		ENSG00000163823	ENSG00000128294
Uniprot IDs		P32246 Q5U003	A0A024R1G9 O60704
PDB IDs		1Y5D	3AP1 3AP2 3AP3
Enriched GO Terms of Interacting Partners?
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