CCR1 and QSOX1

Data Source:
BioGRID (two hybrid)

		CCR1	QSOX1
Description		C-C motif chemokine receptor 1	quiescin sulfhydryl oxidase 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Integral Component Of Golgi Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Intracellular Membrane-bounded Organelle Intercellular Bridge Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Disulfide Isomerase Activity Flavin-linked Sulfhydryl Oxidase Activity FAD Binding
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	Platelet Degranulation Protein Folding Negative Regulation Of Macroautophagy Protein Phosphopantetheinylation Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Extracellular Matrix Assembly
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)	Anorexia nervosa ( 23568457) Blood protein levels ( 29875488) Pulse pressure ( 30224653 30578418)
Interacting Genes		29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	6 interacting genes: BEGAIN CCR1 CCR6 CHRM4 UBE2D2 UBQLN4
Entrez ID		1230	5768
HPRD ID		03101	06785
Ensembl ID		ENSG00000163823	ENSG00000116260
Uniprot IDs		P32246 Q5U003	A0A140VKE5 O00391 Q13876
PDB IDs		1Y5D	3LLI 3LLK 3Q6O 4IJ3
Enriched GO Terms of Interacting Partners?
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