TPST2 and CCR8

Data Source:
HPRD (in vitro)

		TPST2	CCR8
Description		tyrosylprotein sulfotransferase 2	C-C motif chemokine receptor 8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity	Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Peptidyl-tyrosine Sulfation Protein Phosphopantetheinylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Chemotaxis Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		5 interacting genes: CCR1 CCR8 CMKLR1 GPR1 SELPLG	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		8459	1237
HPRD ID		07217	03497
Ensembl ID		ENSG00000128294	ENSG00000179934
Uniprot IDs		A0A024R1G9 O60704	P51685
PDB IDs		3AP1 3AP2 3AP3
Enriched GO Terms of Interacting Partners?
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