CCR1 and GRAMD1A

Data Source:
BioGRID (two hybrid)

		CCR1	GRAMD1A
Description		C-C motif chemokine receptor 1	GRAM domain containing 1A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Autophagosome Cytosol Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Binding Cholesterol Binding Cholesterol Transfer Activity
	Biological Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis	Autophagy Sterol Transport Cellular Response To Cholesterol Intermembrane Lipid Transfer
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 30572963 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)	Cognitive decline (age-related) ( 28078323) Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		29 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CD74 CREB3 FAN1 GNA14 GRAMD1A JAK1 LETMD1 MBP PLP2 PRNP QSOX1 STAT1 STAT3 TMEFF1 TMX1 TPST1 TPST2	4 interacting genes: CCR1 GMCL1 MAL TLR7
Entrez ID		1230	57655
HPRD ID		03101	11153
Ensembl ID		ENSG00000163823	ENSG00000089351
Uniprot IDs		P32246 Q5U003	B3KQF7 B3KUH3 M0QZ12 Q96CP6
PDB IDs		1Y5D
Enriched GO Terms of Interacting Partners?
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