SERPINA3 and ADAMTS4

Data Source:
HPRD (two hybrid)

		SERPINA3	ADAMTS4
Description		serpin family A member 3	ADAM metallopeptidase with thrombospondin type 1 motif 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding
	Biological Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Platelet degranulation Neutrophil degranulation	Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		12	9507
HPRD ID		00120	04853
Ensembl ID		ENSG00000196136	ENSG00000158859
Uniprot IDs		A0A024R6P0 P01011	O75173
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE	2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?
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