ADAMTS4 and BCAN

Data Source:
HPRD (in vitro)

		ADAMTS4	BCAN
Description		ADAM metallopeptidase with thrombospondin type 1 motif 4	brevican
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Golgi Lumen Extracellular Matrix Anchored Component Of Membrane Lysosomal Lumen Glutamatergic Synapse
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Synapse Maturation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494 27863252)	Blood protein levels ( 30072576 29875488)
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		9507	63827
HPRD ID		04853	02644
Ensembl ID		ENSG00000158859	ENSG00000132692
Uniprot IDs		O75173	Q96GW7
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?
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