ADAMTS4 and MT2A

Data Source:
HPRD (two hybrid)

		ADAMTS4	MT2A
Description		ADAM metallopeptidase with thrombospondin type 1 motif 4	metallothionein 2A
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix Collagen-containing Extracellular Matrix	Nucleus Cytoplasm Cytosol
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs			Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	19 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 TNS2 USP25
Entrez ID		9507	4502
HPRD ID		04853	08863
Ensembl ID		ENSG00000158859	ENSG00000125148
Uniprot IDs		O75173	P02795
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI	1MHU 2MHU
Enriched GO Terms of Interacting Partners?
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