SERPINA3 and KLK4

Data Source:
HPRD (in vitro)

		SERPINA3	KLK4
Description		serpin family A member 3	kallikrein related peptidase 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Secretory Granule
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Metal Ion Binding
	Biological Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation	Proteolysis Extracellular Matrix Disassembly Biomineral Tissue Development Amelogenesis
Pathways		Platelet degranulation Neutrophil degranulation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Amelogenesis imperfecta
GWAS		Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)	Celiac disease ( 23936387) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD	3 interacting genes: SERPINA3 SHBG TYRO3
Entrez ID		12	9622
HPRD ID		00120	04793
Ensembl ID		ENSG00000196136	ENSG00000167749
Uniprot IDs		A0A024R6P0 P01011	A0A0C4DFQ5 Q5BQA0 Q96PT1 Q9Y5K2
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE	2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA 6KBR 6NVB 6O21
Enriched GO Terms of Interacting Partners?
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