ADAMTS4 and SRPX2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ADAMTS4	SRPX2
Description		ADAM metallopeptidase with thrombospondin type 1 motif 4	sushi repeat containing protein X-linked 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Space Cytoplasm Cell Surface Excitatory Synapse Collagen-containing Extracellular Matrix Synaptic Membrane
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization	Angiogenesis Regulation Of Phosphorylation Cell Motility Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases			Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494 27863252)
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	3 interacting genes: ADAMTS4 CTSB PLAUR
Entrez ID		9507	27286
HPRD ID		04853	06726
Ensembl ID		ENSG00000158859	ENSG00000102359
Uniprot IDs		O75173	O60687
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?
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