RASSF1 and MST1

Data Source:
BioGRID (two hybrid)

		RASSF1	MST1
Description		Ras association domain family member 1	macrophage stimulating 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Microtubule Cytoskeleton	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Zinc Ion Binding	Serine-type Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Cell Cycle Arrest Signal Transduction Ras Protein Signal Transduction Regulation Of Microtubule Cytoskeleton Organization	Proteolysis Regulation Of Macrophage Chemotaxis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H2A-S139 Phosphorylation Negative Regulation Of Gluconeogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			Signaling by MST1
Drugs
Diseases		Non-small cell lung cancer Bladder cancer Nasopharyngeal cancer
GWAS		Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 28067908 23128233) Primary sclerosing cholangitis ( 23603763 27992413 21151127) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 19915572 28067908 20228799 25082827 21297633)
Interacting Genes		70 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SAV1 SMARCA4 STK11 STK3 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA	10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2
Entrez ID		11186	4485
HPRD ID		05470	00798
Ensembl ID		ENSG00000068028	ENSG00000173531
Uniprot IDs		Q9NS23	G3XAK1 P26927 Q53GN8
PDB IDs		2KZU	2ASU 4QT8
Enriched GO Terms of Interacting Partners?
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