MST1 and MOB1A

Data Source:
HPRD (in vivo)

		MST1	MOB1A
Description		macrophage stimulating 1	MOB kinase activator 1A
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Nucleoplasm Nucleolus Cytosol Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding	Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Regulation Of Macrophage Chemotaxis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H2A-S139 Phosphorylation Negative Regulation Of Gluconeogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity	Hippo Signaling
Pathways		Signaling by MST1	Signaling by Hippo
Drugs
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 28067908 23128233) Primary sclerosing cholangitis ( 23603763 27992413 21151127) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 19915572 28067908 20228799 25082827 21297633)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2	20 interacting genes: APP CCDC85B CMTM3 FAM118A FAM9B GMEB2 IKZF4 KANK2 KXD1 LZTFL1 MST1 PCYT1A PJA2 PTPN5 SEPTIN3 STRN3 TDO2 TMEM190 TRIM32 WASHC3
Entrez ID		4485	55233
HPRD ID		00798	14727
Ensembl ID		ENSG00000173531	ENSG00000114978
Uniprot IDs		G3XAK1 P26927 Q53GN8	Q9H8S9
PDB IDs		2ASU 4QT8	1PI1 4J1V 4JIZ 5BRK 5BRM 5TWF 5TWG 5TWH 5XQZ 6MCP 6MCQ
Enriched GO Terms of Interacting Partners?
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