MST1 and TNNT2

Data Source:
BioGRID (enzymatic study)

		MST1	TNNT2
Description		macrophage stimulating 1	troponin T2, cardiac type
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding	Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding
	Biological Process	Proteolysis Regulation Of Macrophage Chemotaxis Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Histone H2A-S139 Phosphorylation Negative Regulation Of Gluconeogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity	Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Signaling by MST1	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 28067908 23128233) Primary sclerosing cholangitis ( 23603763 27992413 21151127) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 19915572 28067908 20228799 25082827 21297633)	Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2	16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69
Entrez ID		4485	7139
HPRD ID		00798	01844
Ensembl ID		ENSG00000173531	ENSG00000118194
Uniprot IDs		G3XAK1 P26927 Q53GN8	A0A0A0MRJ5 P45379 Q15607
PDB IDs		2ASU 4QT8	1J1D 1J1E 4Y99 6KN7 6KN8
Enriched GO Terms of Interacting Partners?
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