RASSF1 and KCNE3

Data Source:
BioGRID (two hybrid)

		RASSF1	KCNE3
Description		Ras association domain family member 1	potassium voltage-gated channel subfamily E regulatory subunit 3
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Microtubule Cytoskeleton	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Vesicle Neuronal Cell Body Membrane Perikaryon Membrane Raft
	Molecular Function	Protein Binding Zinc Ion Binding	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Cell Cycle Arrest Signal Transduction Ras Protein Signal Transduction Regulation Of Microtubule Cytoskeleton Organization	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways			Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs			Enflurane Promethazine Miconazole
Diseases		Non-small cell lung cancer Bladder cancer Nasopharyngeal cancer	Brugada syndrome (BRS)
GWAS		Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)
Interacting Genes		70 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SAV1 SMARCA4 STK11 STK3 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA	10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1
Entrez ID		11186	10008
HPRD ID		05470	07256
Ensembl ID		ENSG00000068028	ENSG00000175538
Uniprot IDs		Q9NS23	Q6IAE6 Q9Y6H6
PDB IDs		2KZU	2NDJ 6V00 6V01
Enriched GO Terms of Interacting Partners?
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