ZWINT and MIS12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		ZWINT	MIS12
Description		ZW10 interacting kinetochore protein	MIS12 kinetochore complex component
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytoplasm Cytosol Nuclear Body Dendrite	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol
	Molecular Function	Protein Binding Protein N-terminus Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Establishment Of Localization In Cell	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)	Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10	10 interacting genes: CBX3 CBX5 DSN1 HSP90AA1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		11130	79003
HPRD ID		18366	12379
Ensembl ID		ENSG00000122952	ENSG00000167842
Uniprot IDs		O95229	A8K1M4 Q9H081
PDB IDs			5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?