MIS12 and KNL1

Data Source:
HPRD (in vitro, in vivo)

		MIS12	KNL1
Description		MIS12 kinetochore complex component	kinetochore scaffold 1
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)	Anxiety and stress-related disorders ( 31116379)
Interacting Genes		10 interacting genes: CBX3 CBX5 DSN1 HSP90AA1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT	6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK
Entrez ID		79003	57082
HPRD ID		12379	10634
Ensembl ID		ENSG00000167842	ENSG00000137812
Uniprot IDs		A8K1M4 Q9H081	Q8NG31
PDB IDs		5LSJ 5LSK	3SI5 4A1G 4NF9 4NFA
Enriched GO Terms of Interacting Partners?
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