ZWINT and BCAS2

Data Source:
BioGRID (two hybrid)

		ZWINT	BCAS2
Description		ZW10 interacting kinetochore protein	BCAS2 pre-mRNA processing factor
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytoplasm Cytosol Nuclear Body Dendrite	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Protein N-terminus Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Establishment Of Localization In Cell	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)	Autism ( 24189344) Chronotype ( 30696823)
Interacting Genes		17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10	61 interacting genes: ACY1 AIMP2 BLK C10orf82 C9orf24 CCDC120 CCDC17 ECM1 EMILIN3 ENKD1 EP300 ESR1 ESR2 FAM86C1P GOLGA2 HGS HSF2BP IFI35 IKZF3 KRT20 KRT27 KRT31 KRT34 KRT35 KRT36 KRT37 KRT40 KRT75 KRTAP19-6 KRTAP8-1 LMO1 LMO2 LMO3 LMO4 MED29 MIIP MYOZ3 OIP5 PAX5 PCBD2 PFDN5 PGR PLAGL2 PLEKHF2 POT1 PPARG PPP1R32 SF1 SMARCD1 SNRNP200 SNRPC TCF4 TCHP TP53BP2 TRAF1 TXN2 TXNRD2 UBC USHBP1 YPEL3 ZWINT
Entrez ID		11130	10286
HPRD ID		18366	05777
Ensembl ID		ENSG00000122952	ENSG00000116752
Uniprot IDs		O95229	B2R7W3 O75934
PDB IDs			5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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