BCAS2 and ZWINT

Data Source:
BioGRID (two hybrid)

		BCAS2	ZWINT
Description		BCAS2 pre-mRNA processing factor	ZW10 interacting kinetochore protein
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytoplasm Cytosol Nuclear Body Dendrite
	Molecular Function	Protein Binding	Protein Binding Protein N-terminus Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Division Establishment Of Localization In Cell
Pathways		mRNA Splicing - Major Pathway	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Autism ( 24189344) Chronotype ( 30696823)	Cardiac hypertrophy ( 21348951) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)
Interacting Genes		61 interacting genes: ACY1 AIMP2 BLK C10orf82 C9orf24 CCDC120 CCDC17 ECM1 EMILIN3 ENKD1 EP300 ESR1 ESR2 FAM86C1P GOLGA2 HGS HSF2BP IFI35 IKZF3 KRT20 KRT27 KRT31 KRT34 KRT35 KRT36 KRT37 KRT40 KRT75 KRTAP19-6 KRTAP8-1 LMO1 LMO2 LMO3 LMO4 MED29 MIIP MYOZ3 OIP5 PAX5 PCBD2 PFDN5 PGR PLAGL2 PLEKHF2 POT1 PPARG PPP1R32 SF1 SMARCD1 SNRNP200 SNRPC TCF4 TCHP TP53BP2 TRAF1 TXN2 TXNRD2 UBC USHBP1 YPEL3 ZWINT	17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10
Entrez ID		10286	11130
HPRD ID		05777	18366
Ensembl ID		ENSG00000116752	ENSG00000122952
Uniprot IDs		B2R7W3 O75934	O95229
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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