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ADAP1 and PRKCI
Data Source:
HPRD
(in vitro)
ADAP1
PRKCI
Description
ArfGAP with dual PH domains 1
protein kinase C iota
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Intracellular Membrane-bounded Organelle
Golgi Membrane
Nucleus
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Bicellular Tight Junction
Microtubule Cytoskeleton
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Inositol 1,3,4,5 Tetrakisphosphate Binding
Metal Ion Binding
Phosphatidylinositol Bisphosphate Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Phospholipid Binding
Metal Ion Binding
Biological Process
Cell Surface Receptor Signaling Pathway
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Peptidyl-serine Phosphorylation
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Response To Interleukin-1
Bicellular Tight Junction Assembly
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Nuclear signaling by ERBB4
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
Drugs
Tamoxifen
Bisindolylmaleimide I
Fostamatinib
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Platelet distribution width (
32888494
)
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
31511532
)
Interacting Genes
24 interacting genes:
ANP32A
AP3B2
CSNK1A1
DVL3
GADD45A
GOLGA2
GSK3B
NCL
PIK3CA
PLEKHF2
PRKCA
PRKCE
PRKCI
PRKCZ
PRKD1
PSME3
PURA
RANBP9
RPS9
SDCBP2
SF3A3
SRSF2
SUB1
SUPV3L1
52 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
RPA2
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
Entrez ID
11033
5584
HPRD ID
09733
02105
Ensembl ID
ENSG00000105963
ENSG00000163558
Uniprot IDs
A8K3A2
B4DUZ7
O75689
P41743
PDB IDs
3FEH
3FM8
3LJU
3MDB
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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