GADD45G and HP

Data Source:
BioGRID (two hybrid)

		GADD45G	HP
Description		growth arrest and DNA damage inducible gamma	haptoglobin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Activation Of MAPKKK Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade	Acute Inflammatory Response Receptor-mediated Endocytosis Defense Response Acute-phase Response Positive Regulation Of Cell Death Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways			Scavenging of heme from plasma Neutrophil degranulation
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32203549 32154731)	Blood protein levels ( 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		72 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763	21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		10912	3240
HPRD ID		05383	00772
Ensembl ID		ENSG00000130222	ENSG00000257017
Uniprot IDs		O95257	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs		2WAL 3FFM	4WJG 4X0L 5HU6 6TB2
Enriched GO Terms of Interacting Partners?
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