HP and ATP7B

Data Source:
BioGRID (two hybrid)

		HP	ATP7B
Description		haptoglobin	ATPase copper transporting beta
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen	Golgi Membrane Mitochondrion Late Endosome Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding ATP Binding P-type Divalent Copper Transporter Activity
	Biological Process	Acute Inflammatory Response Receptor-mediated Endocytosis Defense Response Acute-phase Response Positive Regulation Of Cell Death Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process	Copper Ion Transport Cellular Copper Ion Homeostasis Copper Ion Import Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Copper Ion Export Inorganic Cation Transmembrane Transport
Pathways		Scavenging of heme from plasma Neutrophil degranulation	Ion transport by P-type ATPases
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases			Wilson disease; Hepatolenticular degeneration
GWAS		Blood protein levels ( 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)	Clostridium difficile infection in multiple myeloma ( 29594489) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL	4 interacting genes: ATOX1 DCTN4 HP ZBTB16
Entrez ID		3240	540
HPRD ID		00772	06050
Ensembl ID		ENSG00000257017	ENSG00000123191
Uniprot IDs		A0A0C4DGL8 P00738 Q6PEJ8	A0A024RDX3 A0A669KB88 B7ZLR3 B7ZLR4 E7ET55 P35670
PDB IDs		4WJG 4X0L 5HU6 6TB2	2ARF 2EW9 2KOY 2LQB 2N7Y 2ROP 6A71 6A72
Enriched GO Terms of Interacting Partners?
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