GADD45G and GRAMD4

Data Source:
BioGRID (two hybrid)

		GADD45G	GRAMD4
Description		growth arrest and DNA damage inducible gamma	GRAM domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding	Molecular_function Protein Binding
	Biological Process	Activation Of MAPKKK Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade	Apoptotic Process Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32203549 32154731)	Urate levels in obese individuals ( 25811787)
Interacting Genes		72 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763	13 interacting genes: APP C2CD6 CCDC146 EXOC8 FAM9B GADD45G MTMR9 NTAQ1 PLEKHF2 RBL2 SH2D4A SMARCD1 TACC2
Entrez ID		10912	23151
HPRD ID		05383	11107
Ensembl ID		ENSG00000130222	ENSG00000075240
Uniprot IDs		O95257	Q6IC98
PDB IDs		2WAL 3FFM
Enriched GO Terms of Interacting Partners?
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