GADD45G and PTPRK

Data Source:
HPRD (two hybrid)

		GADD45G	PTPRK
Description		growth arrest and DNA damage inducible gamma	protein tyrosine phosphatase receptor type K
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Integral Component Of Membrane Cell Junction Leading Edge Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Gamma-catenin Binding
	Biological Process	Activation Of MAPKKK Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Focal Adhesion Assembly
Pathways			EGFR downregulation
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638) Triglyceride levels ( 32203549 32154731)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Celiac disease ( 22057235 20190752 30572963) Crohn's disease ( 28067908) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hodgkin's lymphoma ( 29196614) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple sclerosis ( 21833088) Nodular sclerosis Hodgkin lymphoma ( 29196614) Reaction time ( 29844566) Uterine fibroid size (maximum volume) ( 30196971) Waist circumference ( 28552196)
Interacting Genes		72 interacting genes: ACTN1 AFAP1L1 APP ARPC5L BEND7 BLOC1S2 CCNB1 CDK1 CDKN1A CEP57L1 CFAP44 CNOT9 CRIP2 DCTN2 DDAH2 DDIT4L EEF1A1 EEF1G EIF3G ENKD1 ESR1 EZH2 FAM156A FAM156B GADD45B GADD45GIP1 GDF9 GRAMD4 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN NMB PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RASSF10 RBM48 RCN1 RDH13 REL RRP7A RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579 ZNF664 ZNF763	8 interacting genes: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM TK1
Entrez ID		10912	5796
HPRD ID		05383	03968
Ensembl ID		ENSG00000130222	ENSG00000152894
Uniprot IDs		O95257	B4DHC3 Q15262 Q59EZ1 Q5TG12 Q86WJ2
PDB IDs		2WAL 3FFM	2C7S
Enriched GO Terms of Interacting Partners?
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