POLD3 and REV1

Data Source:
BioGRID (pull down)

		POLD3	REV1
Description		DNA polymerase delta 3, accessory subunit	REV1 DNA directed polymerase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleoplasm
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Deoxycytidyl Transferase Activity Metal Ion Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair	DNA Replication Response To UV Translesion Synthesis Error-prone Translesion Synthesis Error-free Translesion Synthesis
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755 25990418 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29691431 29313844) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)	Bipolar disorder ( 21926972)
Interacting Genes		8 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1 SPRTN	13 interacting genes: CLK1 FAAP20 FHL2 MAD2L2 POLD3 POLDIP2 POLH POLI POLK POLL REV3L TSC22D2 UBC
Entrez ID		10714	51455
HPRD ID		11446	16202
Ensembl ID		ENSG00000077514	ENSG00000135945
Uniprot IDs		A0A024R5M8 Q15054	Q49AI5 Q9UBZ9
PDB IDs		1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ	2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD
Enriched GO Terms of Interacting Partners?
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