POLD3 and POLD4

Data Source:
BioGRID (pull down)

		POLD3	POLD4
Description		DNA polymerase delta 3, accessory subunit	DNA polymerase delta 4, accessory subunit
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755 25990418 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29691431 29313844) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		8 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1 SPRTN	9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		10714	57804
HPRD ID		11446	17873
Ensembl ID		ENSG00000077514	ENSG00000175482
Uniprot IDs		A0A024R5M8 Q15054	A0A024R5D7 Q6NSD7 Q9HCU8
PDB IDs		1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ	6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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