POLD3 and MBD3L2

Data Source:
BioGRID (pull down)

		POLD3	MBD3L2
Description		DNA polymerase delta 3, accessory subunit	methyl-CpG binding domain protein 3 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Zeta DNA Polymerase Complex Delta DNA Polymerase Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding
	Biological Process	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Strand Elongation Involved In DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage DNA Biosynthetic Process DNA Synthesis Involved In UV-damage Excision Repair
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Colorectal cancer ( 22634755 25990418 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Hand grip strength ( 29691431 29313844) Microalbuminuria ( 26631737) Renal underexcretion gout ( 32238385) Response to metformin (IC50) ( 28173075)
Interacting Genes		8 interacting genes: APP MBD3L2 PCNA POLD1 POLD2 POLD4 REV1 SPRTN	20 interacting genes: CCDC136 CHD4 GOLGA6L9 GPRASP2 HDAC1 HDAC2 KRT27 KRT34 KRTAP6-3 MBD2 MBD3 MDFI MTA1 MTA2 POLD3 RBBP4 RBBP7 RUNDC3A SBK3 TRIML2
Entrez ID		10714	125997
HPRD ID		11446	12139
Ensembl ID		ENSG00000077514	ENSG00000230522
Uniprot IDs		A0A024R5M8 Q15054	Q8NHZ7
PDB IDs		1U76 2N1G 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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