REV1 and POLK

Data Source:
HPRD (in vitro)

		REV1	POLK
Description		REV1 DNA directed polymerase	DNA polymerase kappa
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GO Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Nuclear Body Site Of DNA Damage
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Deoxycytidyl Transferase Activity Metal Ion Binding	Damaged DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding
	Biological Process	DNA Replication Response To UV Translesion Synthesis Error-prone Translesion Synthesis Error-free Translesion Synthesis	DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Cellular Response To DNA Damage Stimulus Translesion Synthesis Nucleotide-excision Repair, DNA Incision Cellular Response To UV Error-prone Translesion Synthesis
Pathways		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis	Translesion synthesis by POLK Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
Diseases
GWAS		Bipolar disorder ( 21926972)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Iron status biomarkers (transferrin saturation) ( 28334935)
Interacting Genes		13 interacting genes: CLK1 FAAP20 FHL2 MAD2L2 POLD3 POLDIP2 POLH POLI POLK POLL REV3L TSC22D2 UBC	5 interacting genes: PCNA RAD18 REV1 TRAIP WRN
Entrez ID		51455	51426
HPRD ID		16202	09291
Ensembl ID		ENSG00000135945	ENSG00000122008
Uniprot IDs		Q49AI5 Q9UBZ9	A0A024RAP4 Q9UBT6
PDB IDs		2EBW 2LSI 2LSK 2LSY 2N1G 3GQC 3VU7 4BA9 4EXT 4GK0 4GK5 5VZM 6ASR 6AXD	1T94 2LSI 2OH2 2W7O 2W7P 3IN5 3PZP 4BA9 4GK5 4U6P 4U7C 5T14 5W2A 5W2C 6BRX 6BS1 6CST
Enriched GO Terms of Interacting Partners?
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