PGRMC2 and PEDS1-UBE2V1

Data Source:
BioGRID (two hybrid)

		PGRMC2	PEDS1-UBE2V1
Description		progesterone receptor membrane component 2	PEDS1-UBE2V1 readthrough
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endomembrane System Membrane Integral Component Of Membrane
	Molecular Function	Steroid Hormone Receptor Activity Steroid Binding Protein Binding Heme Transmembrane Transporter Activity Heme Binding
	Biological Process	Heme Transport Steroid Hormone Mediated Signaling Pathway Adipose Tissue Development
Pathways			NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bone mineral density (total hip) ( 29883787)
Interacting Genes		57 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LPAR3 MALL MFHAS1 MFSD5 ORMDL1 PEDS1-UBE2V1 PEX16 PGRMC1 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VAPA VEZT YIPF2 ZDHHC21 ZFPL1	17 interacting genes: AQP6 CNR2 CREB3L1 FAM209A GPR152 PGRMC2 SLC10A1 SLC10A6 SLC18A3 SLC30A4 STOM TMEM31 TMEM52B TMX2 TRAF6 TRHR UBE2N
Entrez ID		10424	387522
HPRD ID		09665	11926
Ensembl ID		ENSG00000164040	ENSG00000124208
Uniprot IDs		O15173	A5PLL7 Q13404
PDB IDs			2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?
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