PEDS1-UBE2V1 and TRHR

Data Source:
BioGRID (two hybrid)

		PEDS1-UBE2V1	TRHR
Description		PEDS1-UBE2V1 readthrough	thyrotropin releasing hormone receptor
Image			No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function		Thyrotropin-releasing Hormone Receptor Activity Protein Binding
	Biological Process		G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Protirelin
Diseases
GWAS			Body mass (lean) ( 19268274) Daytime sleep phenotypes ( 27126917) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969)
Interacting Genes		17 interacting genes: AQP6 CNR2 CREB3L1 FAM209A GPR152 PGRMC2 SLC10A1 SLC10A6 SLC18A3 SLC30A4 STOM TMEM31 TMEM52B TMX2 TRAF6 TRHR UBE2N	19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6
Entrez ID		387522	7201
HPRD ID		11926	11767
Ensembl ID		ENSG00000124208	ENSG00000174417
Uniprot IDs		A5PLL7 Q13404	P34981
PDB IDs		2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?
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