IKZF1 and CTBP1

Data Source:
HPRD (in vivo)

		IKZF1	CTBP1
Description		IKAROS family zinc finger 1	C-terminal binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Metal Ion Binding	RNA Polymerase II Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cell Cycle Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation
Pathways			Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs			Formic acid
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 29296818) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) Asthma ( 32296059) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 28334899) Height ( 28552196) Hemoglobin ( 32888494) Hemoglobin levels ( 28017375) High density lipoprotein cholesterol levels ( 29403010) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 28453575 27863252 28017375 19862010) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010) Type 1 diabetes ( 25751624)	Type 2 diabetes ( 31118516 32499647)
Interacting Genes		108 interacting genes: AEN ALKBH3 ANKRD11 ANKRD36 AP1M1 AP2M1 ARMC7 BARD1 BYSL C1orf109 C1orf174 C8orf33 CBX8 CCDC185 CDC7 CDK2AP2 CDKL3 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CTBP2 CWF19L2 DCX DDB1 DDX6 DYRK2 FAM161A FAM214B FAM50B FAM74A4 FGF12 FHL2 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO1 LMO2 LMO3 LMO4 LSM4 MAD2L2 MAGOHB MAPRE3 MCRS1 MEOX2 MORF4L1 MORF4L2 MOS MPPED2 NEK6 NME7 NOC4L NUDT21 PIAS2 PIN1 PNKP PPL PRKAA2 PRKAB2 PRPF18 PSMA1 PSMA4 QARS1 RAD51D RBBP8 RBM43 RNF4 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPA1 SNRPF SNW1 SPATC1L SYT17 TBP TCEA2 TDG TSTD2 TXK UBE2I WTAP ZMAT2 ZNF417 ZNF580 ZNF581 ZNF587	92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219
Entrez ID		10320	1487
HPRD ID		04318	04015
Ensembl ID		ENSG00000185811	ENSG00000159692
Uniprot IDs		A0A2R8Y4D3 C9JTB0 Q13422 R9R4D9	Q13363 X5D8Y5
PDB IDs		6H0F	1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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