CTBP1 and KLF12

Data Source:
HPRD (in vivo, in vitro)

		CTBP1	KLF12
Description		C-terminal binding protein 1	Kruppel like factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex	Chromatin Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Bronchopulmonary dysplasia ( 23897914) Colorectal cancer ( 30529582) Craniofacial microsomia ( 26853712) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Energy expenditure ( 30071075) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Heel bone mineral density ( 30598549 28869591) Heschl's gyrus morphology ( 25130324) Lean body mass ( 28724990) Long QT syndrome ( 32429735) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Neurofibrillary tangles ( 25188341) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 29422604 20101243 26098869 25086665) Phospholipid levels (plasma) ( 22359512) Photic sneeze reflex ( 27182965) QRS duration ( 30679814 27577874 30012220 21076409 27659466) QT interval ( 24952745 29874175) Refractive error ( 32231278) Systemic lupus erythematosus ( 19838195) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438) Waist-to-hip ratio adjusted for body mass index ( 27195708) White blood cell count ( 32888494)
Interacting Genes		92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	7 interacting genes: APP CTBP1 DNMT3L EHMT2 FHL2 FHL3 THAP1
Entrez ID		1487	11278
HPRD ID		04015	06336
Ensembl ID		ENSG00000159692	ENSG00000118922
Uniprot IDs		Q13363 X5D8Y5	Q8WWI3 Q9Y4X4
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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