CTBP1 and LCORL

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid)

		CTBP1	LCORL
Description		C-terminal binding protein 1	ligand dependent nuclear receptor corepressor like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex	Nucleus
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding	DNA Binding Protein Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation	Regulation Of Transcription By RNA Polymerase II
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	Adult body size ( 32376654) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Alzheimer's disease progression score ( 29860282) Birth length ( 25281659) Birth weight ( 23202124 31043758 27680694) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Colorectal cancer (diet interaction) ( 24743840) Diverticular disease ( 30177863) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 22021425 25282103 25429064 19343178 23563607 31562340 28270201 18391951 18391952 20189936) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Offspring birth weight ( 31043758) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	4 interacting genes: CTBP1 CTBP2 MAGEA6 MIR206
Entrez ID		1487	254251
HPRD ID		04015	10088
Ensembl ID		ENSG00000159692	ENSG00000178177
Uniprot IDs		Q13363 X5D8Y5	A0A1B0GVP4 B4DSW0 Q8N3X6
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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