IKZF1 and ZNF581

Data Source:
BioGRID (two hybrid)

		IKZF1	ZNF581
Description		IKAROS family zinc finger 1	zinc finger protein 581
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol Protein-containing Complex	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Cell Cycle Mesoderm Development Lymphocyte Differentiation Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299 29296818) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Area under the curve of insulin levels ( 24699409) Aspartate aminotransferase levels ( 29403010) Asthma ( 32296059) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe mucosal involvement ( 25672763) Crohn's disease ( 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 28334899) Height ( 28552196) Hemoglobin ( 32888494) Hemoglobin levels ( 28017375) High density lipoprotein cholesterol levels ( 29403010) Hippocampal atrophy ( 19668339) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 28453575 27863252 28017375 19862010) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602) N-glycan levels ( 31163085) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 28714469 19838193 19838195) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 29403010) Type 1 diabetes ( 25751624)
Interacting Genes		108 interacting genes: AEN ALKBH3 ANKRD11 ANKRD36 AP1M1 AP2M1 ARMC7 BARD1 BYSL C1orf109 C1orf174 C8orf33 CBX8 CCDC185 CDC7 CDK2AP2 CDKL3 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CTBP2 CWF19L2 DCX DDB1 DDX6 DYRK2 FAM161A FAM214B FAM50B FAM74A4 FGF12 FHL2 FOXP1 FRMD6 GLRX3 GMCL2 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LHX4 LMO1 LMO2 LMO3 LMO4 LSM4 MAD2L2 MAGOHB MAPRE3 MCRS1 MEOX2 MORF4L1 MORF4L2 MOS MPPED2 NEK6 NME7 NOC4L NUDT21 PIAS2 PIN1 PNKP PPL PRKAA2 PRKAB2 PRPF18 PSMA1 PSMA4 QARS1 RAD51D RBBP8 RBM43 RNF4 RNF6 RUNX1 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SHFL SIN3A SIN3B SMARCA4 SNRPA1 SNRPF SNW1 SPATC1L SYT17 TBP TCEA2 TDG TSTD2 TXK UBE2I WTAP ZMAT2 ZNF417 ZNF580 ZNF581 ZNF587	95 interacting genes: AP2M1 APOBEC3C APP ASB13 ATG9A BANP BOLA2 BOLA2B CALCOCO2 CARD10 CBY2 CCDC136 CCNDBP1 CHURC1 CNFN CYSRT1 DAZAP2 DOCK8 DVL2 DVL3 EFEMP2 ENKD1 ETFDH FAM90A1 FANCL FHL5 FSD2 GOLGA2 GOLGA6L9 GOPC GPSM3 HMBOX1 HNRNPC HNRNPF HSF2BP IKZF1 IL16 KDM1A KHDRBS2 KRT27 KRT34 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-2 LNX1 LNX2 LZTS2 MDFI MGAT5B MTUS2 NBPF19 NID2 NOTCH2NLA NUDT22 PDE4DIP PLAGL2 PLEKHF2 PLSCR1 PNMA1 POU2AF1 PRKAB2 RBPMS RIMBP3C RSKR SDCBP2 SERTAD2 SMARCC1 SOX5 SPAG8 SPG21 SUV39H1 TEKT4 TMCC2 TRAF1 TRAF4 TRIM23 TRIM27 TRIM55 TRIM63 TRIP6 WWOX ZNF765 ZNF792 ZRANB1
Entrez ID		10320	51545
HPRD ID		04318	15858
Ensembl ID		ENSG00000185811	ENSG00000171425
Uniprot IDs		A0A2R8Y4D3 C9JTB0 Q13422 R9R4D9	Q9P0T4
PDB IDs		6H0F
Enriched GO Terms of Interacting Partners?
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