CTBP1 and DGCR6

Data Source:
BioGRID (two hybrid)

		CTBP1	DGCR6
Description		C-terminal binding protein 1	DiGeorge syndrome critical region gene 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex	Nucleus Extracellular Matrix
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation	Cell Adhesion Animal Organ Morphogenesis
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs		Formic acid
Diseases
GWAS		Type 2 diabetes ( 31118516 32499647)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	66 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446
Entrez ID		1487	8214
HPRD ID		04015	03177
Ensembl ID		ENSG00000159692	ENSG00000183628
Uniprot IDs		Q13363 X5D8Y5	Q14129 X5D7D2
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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