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CDK7 and THRA
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
CDK7
THRA
Description
cyclin dependent kinase 7
thyroid hormone receptor alpha
Image
GO Annotations
Cellular Component
Transcription Factor TFIIH Core Complex
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cytoplasm
Cytosol
Plasma Membrane
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
Perinuclear Region Of Cytoplasm
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
TBP-class Protein Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein-containing Complex Binding
Thyroid Hormone Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Cell Cycle Arrest
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Cell Division
Phosphorylation Of RNA Polymerase II C-terminal Domain
Negative Regulation Of Transcription By RNA Polymerase II
Cartilage Condensation
Ossification
Thyroid Hormone Mediated Signaling Pathway
Regulation Of Thyroid Hormone Mediated Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Learning Or Memory
Regulation Of Heart Contraction
Female Courtship Behavior
Response To Cold
Hormone-mediated Signaling Pathway
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Cell Differentiation
Erythrocyte Differentiation
Thyroid Gland Development
Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Female Receptivity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Lipid Catabolic Process
Type I Pneumocyte Differentiation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of DNA-templated Transcription, Initiation
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Nuclear Receptor transcription pathway
Drugs
Phosphonothreonine
Alvocidib
SNS-032
Seliciclib
Liothyronine
Levothyroxine
Dextrothyroxine
Amiodarone
Liotrix
KB-141
Dronedarone
Eprotirome
NRP409
Thyroid, porcine
Diseases
GWAS
Asthma (
31619474
)
Bipolar disorder (
31043756
)
Chronic obstructive pulmonary disease (
30804561
)
Pancreatic ductal adenocarcinoma (
30541042
)
White blood cell count (
21738480
)
Interacting Genes
45 interacting genes:
APP
AR
BRCA1
CCND2
CCNH
CDC37
CDK1
CDK2
CDK6
CDK9
CTDP1
CUX1
E2F1
ERCC2
ERCC3
ESR1
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H5
H1-1
HLA-DQA1
HSD17B4
LASP1
MBP
MCM7
MNAT1
NEK6
PCGF6
POLR2A
POLR2B
PRKCI
RARA
SMAD1
SRPK1
SRPK2
SUPT5H
TAF7
TCEA1
THRA
TP53
UBE2D1
VDR
69 interacting genes:
-
AKAP13
AMOT
AMOTL2
ARID5A
BTG1
BUB3
C1D
CCND1
CD160
CDK7
CEP76
CLIC1
COPS2
CREB1
CREBBP
CUL1
DAP3
ESR1
FOXJ1
FUS
GRIP1
GTF2B
HDAC2
HDAC3
ITGB3BP
L3MBTL3
MED1
MED21
MED25
MEF2A
MEOX2
MTNR1B
NCOA1
NCOA2
NCOA6
NCOR1
NCOR2
NR0B2
NR2F1
NRIP1
NSD1
OASL
PML
POU2F1
PRKAR1B
PRKDC
PTGES3
RANBP9
RGN
RXRA
RXRB
RXRG
SELENOP
SLC16A2
SRC
SUV39H1
SYAP1
TACC1
TBL1X
TDG
TRIM24
TRIM63
TRIP11
TXNRD1
UBE2I
YWHAH
YWHAQ
ZBTB3
Entrez ID
1022
7067
HPRD ID
15993
07185
Ensembl ID
ENSG00000134058
ENSG00000126351
Uniprot IDs
A0A0S2Z3F9
D6R9G1
D6RFL0
P50613
P10827
Q6FH41
PDB IDs
1LG3
1PA8
1UA2
2HIC
6O9L
6XBZ
6XD3
1NAV
2H77
2H79
3HZF
3ILZ
3JZB
4LNW
4LNX
Enriched GO Terms of Interacting Partners
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