THRA and CCND1

Data Source:
HPRD (in vivo)

		THRA	CCND1
Description		thyroid hormone receptor alpha	cyclin D1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Bicellular Tight Junction Transcription Repressor Complex Nuclear Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Thyroid Hormone Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Mediated Signaling Pathway Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription, Initiation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Response To Leptin Mitotic Cell Cycle Phase Transition Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Cell Division Response To Corticosterone Response To Calcium Ion Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Nuclear Receptor transcription pathway	SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine	Acetylsalicylic acid Arsenic trioxide Encorafenib Bryostatin 1
Diseases			Hairy-cell leukemia von Hippel-Lindau syndrome Esophageal cancer Oral cancer Multiple myeloma Laryngeal cancer Breast cancer
GWAS		Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)	Adult body size ( 32376654) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Breast cancer ( 29059683 20453838) Breast cancer (early onset) ( 24493630) Breast size ( 22747683 27182965) Craniofacial microsomia ( 26853712) Cutaneous malignant melanoma ( 32341527 26237428) Diastolic blood pressure ( 27841878) Height ( 25429064) Hip circumference ( 25673412) Idiopathic dilated cardiomyopathy ( 29495422) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Melanoma ( 28212542) Multiple myeloma (IgH translocation) ( 23502783) Nevus count or cutaneous melanoma ( 32341527 30429480) Offspring birth weight ( 31043758) Refractive error ( 32231278) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30297969 32499647 30718926) White blood cell count ( 32888494)
Interacting Genes		69 interacting genes: - AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3	80 interacting genes: AKAP8 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDC14B CDH13 CDK4 CDK6 CDK8 CDKN1A CDKN1B CRYAB CTNNB1 CUL3 DMTF1 EP300 ESR1 FANCC FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 IGFBP3 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PPP3R2 PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SMAD1 SP1 STAT3 TAF1 TBC1D2 TDRD7 THRA THRB TP73 TRMO TSC2 TSTD2 UBTF UHRF2 USP2 XPO1 ZNF510
Entrez ID		7067	595
HPRD ID		07185	01346
Ensembl ID		ENSG00000126351	ENSG00000110092
Uniprot IDs		P10827 Q6FH41	P24385 Q6FI00
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX	2W96 2W99 2W9F 2W9Z 5VZU 6P8E 6P8F 6P8G 6P8H
Enriched GO Terms of Interacting Partners?
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