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CDK7 and CTDP1
Data Source:
BioGRID
(enzymatic study)
CDK7
CTDP1
Description
cyclin dependent kinase 7
CTD phosphatase subunit 1
Image
GO Annotations
Cellular Component
Transcription Factor TFIIH Core Complex
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cytoplasm
Cytosol
Plasma Membrane
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
Perinuclear Region Of Cytoplasm
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Spindle
Midbody
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Spindle Midzone
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
TFIIF-class Transcription Factor Complex Binding
Phosphoprotein Phosphatase Activity
Protein Binding
RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity
Tat Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Cell Cycle Arrest
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Cell Division
Phosphorylation Of RNA Polymerase II C-terminal Domain
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
Protein Dephosphorylation
Exit From Mitosis
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Viral Transcription
Cell Division
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Dephosphorylation Of RNA Polymerase II C-terminal Domain
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation
Drugs
Phosphonothreonine
Alvocidib
SNS-032
Seliciclib
Diseases
GWAS
Adverse response to drug (
30420678
)
Cerebrospinal P-tau181p levels (
28247064
)
Metabolite levels (
23823483
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
)
Schizophrenia (
23212062
)
Smoking initiation (ever regular vs never regular) (
30679032
)
Interacting Genes
45 interacting genes:
APP
AR
BRCA1
CCND2
CCNH
CDC37
CDK1
CDK2
CDK6
CDK9
CTDP1
CUX1
E2F1
ERCC2
ERCC3
ESR1
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H5
H1-1
HLA-DQA1
HSD17B4
LASP1
MBP
MCM7
MNAT1
NEK6
PCGF6
POLR2A
POLR2B
PRKCI
RARA
SMAD1
SRPK1
SRPK2
SUPT5H
TAF7
TCEA1
THRA
TP53
UBE2D1
VDR
40 interacting genes:
CDK7
CDK8
CDK9
CSNK2A1
CSNK2A2
CSNK2B
E2F1
ELP2
ELP3
ERH
GTF2F1
INTS1
INTS3
INTS6
INTS7
INTS8
MED1
MED14
MED15
MED16
MED17
MED23
MED24
MED25
MED26
MED4
MED6
MED7
MED8
NDRG2
POLR2A
POLR2B
PRKDC
PRMT5
SNRNP70
SNRPB
STK38
TCEA1
UPP1
WDR77
Entrez ID
1022
9150
HPRD ID
15993
05377
Ensembl ID
ENSG00000134058
ENSG00000060069
Uniprot IDs
A0A0S2Z3F9
D6R9G1
D6RFL0
P50613
A0A0A0MR03
Q9Y5B0
PDB IDs
1LG3
1PA8
1UA2
2HIC
6O9L
6XBZ
6XD3
1J2X
1ONV
2K7L
Enriched GO Terms of Interacting Partners
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