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CDK7 and SRPK1
Data Source:
BioGRID
(enzymatic study)
CDK7
SRPK1
Description
cyclin dependent kinase 7
SRSF protein kinase 1
Image
GO Annotations
Cellular Component
Transcription Factor TFIIH Core Complex
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cytoplasm
Cytosol
Plasma Membrane
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
Perinuclear Region Of Cytoplasm
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Nuclear Matrix
Nuclear Speck
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Magnesium Ion Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Cell Cycle Arrest
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Cell Division
Phosphorylation Of RNA Polymerase II C-terminal Domain
MAPK Cascade
Spliceosomal Complex Assembly
Protein Phosphorylation
Chromosome Segregation
RNA Splicing
Viral Process
Sperm Chromatin Condensation
Intracellular Signal Transduction
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of MRNA Processing
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Phosphonothreonine
Alvocidib
SNS-032
Seliciclib
Diseases
GWAS
Antidepressant treatment resistance (> 2 drugs prescribed) (
30700811
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
45 interacting genes:
APP
AR
BRCA1
CCND2
CCNH
CDC37
CDK1
CDK2
CDK6
CDK9
CTDP1
CUX1
E2F1
ERCC2
ERCC3
ESR1
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H5
H1-1
HLA-DQA1
HSD17B4
LASP1
MBP
MCM7
MNAT1
NEK6
PCGF6
POLR2A
POLR2B
PRKCI
RARA
SMAD1
SRPK1
SRPK2
SUPT5H
TAF7
TCEA1
THRA
TP53
UBE2D1
VDR
170 interacting genes:
ADPRH
AHCYL1
ALKBH3
AMMECR1L
APEX1
APP
ARGLU1
ARHGAP12
ARHGAP26
ASAH1
ASXL1
AURKA
AURKC
C11orf52
C11orf87
C16orf78
C18orf25
C9orf72
CACNB1
CAMK2D
CBX5
CDC42EP3
CDK7
CDKL3
CHEK2
CHERP
CHUK
CIAO1
CLIC5
CLK1
CLK4
CRHR1
CSAG1
DAW1
DDX47
DHX8
DHX9
DNAJC8
DUSP6
ECM1
EIF3M
EPB41L4A
EPHA3
ERBB2
ESRRG
FAM124A
FAM76B
FERMT1
FGF12
FHL1
FKBP3
FLOT1
FLT1
GABARAP
GABARAPL1
HBS1L
HIRIP3
HMGN3
HNRNPA1
IFIT5
IKBKG
JHY
KCNAB1
KCNN2
KIAA1841
KPNA2
KPTN
KRR1
LAMC1
LARP1
LBR
LCE3D
LIMK1
LINC00312
LUC7L3
MACROH2A1
MAGEB1
MAOB
MAP1LC3A
MAPK12
MAPK14
MAPKAPK5
MAPT
MBNL3
MBP
MRPL43
MRPS11
NCK2
NELFE
NKAP
NOL4L
NOP16
NOVA1
NSMCE4A
NSRP1
NUDT21
NXT2
OCEL1
ODF3L2
OR6B3
PAK4
PDGFRA
PDPK1
PELI1
PELI2
PEX19
PFN1
PHF7
POLR2E
PPIA
PPIL1
PRM1
PRPF38A
PTK2
RBM23
RBM39
RBM8A
RBMS2
RIMS4
RNPS1
RPS6KB2
RSRC1
RSRC2
RSRP1
SAFB
SCAF11
SEC23B
SERPINB10
SETD3
SFMBT1
SLAIN2
SLC4A1AP
SNRNP70
SPANXN4
SPATS2
SREK1
SRPK3
SRRM1
SRSF1
SRSF12
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
STAU1
STK26
SUDS3
TAF1B
TFEB
TNFRSF10C
TOP2A
TRA2B
TRIM65
U2AF1
U2AF2
UBD
UBE2E2
USP39
VANGL1
VDR
WDR55
YPEL2
YTHDC1
YWHAG
ZMYND11
ZNF444
ZNF514
ZRANB2
Entrez ID
1022
6732
HPRD ID
15993
15992
Ensembl ID
ENSG00000134058
ENSG00000096063
Uniprot IDs
A0A0S2Z3F9
D6R9G1
D6RFL0
P50613
Q96SB4
PDB IDs
1LG3
1PA8
1UA2
2HIC
6O9L
6XBZ
6XD3
1WAK
1WBP
3BEG
4WUA
5MXX
5MY8
5NNG
5XV7
6FAD
Enriched GO Terms of Interacting Partners
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