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CDK7 and RARA
Data Source:
HPRD
(in vitro, two hybrid)
CDK7
RARA
Description
cyclin dependent kinase 7
retinoic acid receptor alpha
Image
GO Annotations
Cellular Component
Transcription Factor TFIIH Core Complex
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cytoplasm
Cytosol
Plasma Membrane
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
Perinuclear Region Of Cytoplasm
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell Surface
Actin Cytoskeleton
Protein-containing Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein Kinase B Binding
Retinoic Acid-responsive Element Binding
Protein Kinase A Binding
Alpha-actinin Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Phosphorylation
Cell Cycle Arrest
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Cell Division
Phosphorylation Of RNA Polymerase II C-terminal Domain
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Hormone-mediated Signaling Pathway
Cell Differentiation
Negative Regulation Of Granulocyte Differentiation
Response To Retinoic Acid
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Apoptotic Cell Clearance
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Binding
Cellular Response To Estrogen Stimulus
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
Phosphonothreonine
Alvocidib
SNS-032
Seliciclib
Adapalene
Acitretin
Alitretinoin
Tretinoin
Tazarotene
Etretinate
Isotretinoin
Tamibarotene
LGD-1550
Trifarotene
Diseases
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Acute myeloid leukemia (AML)
GWAS
Asthma (
31619474
)
Interacting Genes
45 interacting genes:
APP
AR
BRCA1
CCND2
CCNH
CDC37
CDK1
CDK2
CDK6
CDK9
CTDP1
CUX1
E2F1
ERCC2
ERCC3
ESR1
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H5
H1-1
HLA-DQA1
HSD17B4
LASP1
MBP
MCM7
MNAT1
NEK6
PCGF6
POLR2A
POLR2B
PRKCI
RARA
SMAD1
SRPK1
SRPK2
SUPT5H
TAF7
TCEA1
THRA
TP53
UBE2D1
VDR
97 interacting genes:
ACTN4
AKT1
ALOX15B
ALX1
ARID1A
ARID5A
ARNTL
BAG1
BBS4
BTG1
CCND3
CCNDBP1
CDK7
CEBPA
CLOCK
CNOT1
COPS2
E2F1
ESR1
FGFR1
FN1
FOXO1
GADD45G
GATA2
HDAC1
HDAC3
HDAC4
HMGA1
HR
IRX4
ITGB1BP2
KAT2B
KDM5A
KLF5
LRIF1
MAPK6
MCRS1
MDM2
MECR
MED1
MED25
MED6
MMS19
NCOA1
NCOA2
NCOA3
NCOA6
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR2C1
NR2E3
NR3C1
NRBF2
NRIP1
NRIP2
NSD1
PARP1
PHF8
PIN1
PLEKHF2
PML
PNRC2
POU2F1
PPARG
PRAME
PRDX6
PRKCA
PSMC5
RXRA
RXRB
RXRG
S100A3
SIRT1
SMARCD3
SNW1
SP1
SPEN
SRC
SRF
STAT5B
TADA3
TEKT4
THRB
TNIP1
TOP2B
TRIB3
TRIM24
TRIP4
UBE3A
UBQLN1
USP7
ZBTB16
Entrez ID
1022
5914
HPRD ID
15993
06769
Ensembl ID
ENSG00000134058
ENSG00000131759
Uniprot IDs
A0A0S2Z3F9
D6R9G1
D6RFL0
P50613
A8K840
A8MUP8
F1D8N9
P10276
Q6I9R7
PDB IDs
1LG3
1PA8
1UA2
2HIC
6O9L
6XBZ
6XD3
1DKF
1DSZ
3A9E
3KMR
3KMZ
4DQM
5K13
6XWG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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