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CDK5 and DNM1
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro, in vivo)
CDK5
DNM1
Description
cyclin dependent kinase 5
dynamin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Perikaryon
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Nucleoplasm
Cytoplasm
Microtubule
Plasma Membrane
Postsynaptic Density
Microtubule Cytoskeleton
Membrane
Axon
Cytoplasmic Vesicle
Mitochondrial Membrane
Dendritic Spine Head
Extracellular Exosome
Presynapse
Postsynaptic Endocytic Zone Membrane
Molecular Function
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Protein Kinase Binding
Acetylcholine Receptor Activator Activity
ErbB-3 Class Receptor Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Binding
GTPase Activity
Protein Binding
GTP Binding
Microtubule Binding
Protein Kinase Binding
Identical Protein Binding
Biological Process
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Protein Phosphorylation
Intracellular Protein Transport
Nucleocytoplasmic Transport
Mitochondrion Organization
Cell-matrix Adhesion
Chemical Synaptic Transmission
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Visual Learning
Response To Wounding
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Phosphorylation
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Corpus Callosum Development
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Cortical Actin Cytoskeleton Organization
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Positive Regulation Of Protein Binding
Receptor Catabolic Process
Positive Regulation Of Glial Cell Apoptotic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Serine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Calcium Ion-dependent Exocytosis
Protein Autophosphorylation
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Synapse Pruning
Regulation Of Neurotransmitter Receptor Activity
Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Negative Regulation Of Neuron Death
Positive Regulation Of Voltage-gated Calcium Channel Activity
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Protein Localization To Plasma Membrane
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Positive Regulation Of Actin Cytoskeleton Reorganization
Mitochondrial Fission
Dynamin Family Protein Polymerization Involved In Mitochondrial Fission
Endocytosis
Receptor-mediated Endocytosis
Endosome Organization
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Receptor Internalization
Ephrin Receptor Signaling Pathway
Regulation Of Synapse Structure Or Activity
Membrane Fusion
Postsynaptic Neurotransmitter Receptor Internalization
Pathways
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Factors involved in megakaryocyte development and platelet production
Toll Like Receptor 4 (TLR4) Cascade
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Clathrin-mediated endocytosis
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Attention deficit hyperactivity disorder (
18839057
)
Body mass index (
26426971
)
Coenzyme Q10 levels (
27149984
)
Platelet distribution width (
32888494
)
Interacting Genes
81 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CCNI
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PRKN
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SPDYE4
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
46 interacting genes:
AMPH
AP2A2
ASB13
BIN1
CABIN1
CAV1
CDK5
CEP126
CLIC3
CLIC4
CLINT1
CTTN
DNM2
DNMBP
EPS15
FNBP1
GRB2
GRIN1
GRIN2D
ITSN1
MAP3K10
MED31
MOB4
NCK1
NCK2
NME2
PACSIN1
PACSIN2
PACSIN3
PFN2
PIAS1
PIK3R1
PIN4
PLCG1
PRKCA
PRNP
RACK1
SH3GL1
SH3GL2
SH3GL3
SNAP25
SNX9
SRC
SUMO1
TIMM50
UBE2I
Entrez ID
1020
1759
HPRD ID
00449
03851
Ensembl ID
ENSG00000164885
ENSG00000106976
Uniprot IDs
A0A090N7W4
A0A0S2Z355
Q00535
B4DK06
B7ZAC0
Q05193
PDB IDs
1H4L
1LFR
1UNG
1UNH
1UNL
3O0G
4AU8
1DYN
2DYN
2X2E
2X2F
3SNH
3ZYC
3ZYS
4UUD
4UUK
5D3Q
6DLU
6DLV
6S9A
Enriched GO Terms of Interacting Partners
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