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CDK5 and HTRA2
Data Source:
BioGRID
(enzymatic study)
CDK5
HTRA2
Description
cyclin dependent kinase 5
HtrA serine peptidase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Perikaryon
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Chromatin
Nucleus
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Cytoplasmic Side Of Plasma Membrane
Membrane
Mitochondrial Membrane
CD40 Receptor Complex
Serine-type Endopeptidase Complex
Molecular Function
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Protein Kinase Binding
Acetylcholine Receptor Activator Activity
ErbB-3 Class Receptor Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Serine-type Peptidase Activity
Identical Protein Binding
Unfolded Protein Binding
Biological Process
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Protein Phosphorylation
Intracellular Protein Transport
Nucleocytoplasmic Transport
Mitochondrion Organization
Cell-matrix Adhesion
Chemical Synaptic Transmission
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Visual Learning
Response To Wounding
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Phosphorylation
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Corpus Callosum Development
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Cortical Actin Cytoskeleton Organization
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Positive Regulation Of Protein Binding
Receptor Catabolic Process
Positive Regulation Of Glial Cell Apoptotic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Serine Phosphorylation Of STAT Protein
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Calcium Ion-dependent Exocytosis
Protein Autophosphorylation
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Synapse Pruning
Regulation Of Neurotransmitter Receptor Activity
Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Negative Regulation Of Neuron Death
Positive Regulation Of Voltage-gated Calcium Channel Activity
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Protein Localization To Plasma Membrane
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Positive Regulation Of Actin Cytoskeleton Reorganization
Proteolysis
Ceramide Metabolic Process
Mitochondrion Organization
Aging
Adult Walking Behavior
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Herbicide
Positive Regulation Of Mitochondrion Organization
Programmed Cell Death
Protein Autoprocessing
Pentacyclic Triterpenoid Metabolic Process
Forebrain Development
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Interferon-beta
Regulation Of Multicellular Organism Growth
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Cell Cycle
Neuron Development
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
Factors involved in megakaryocyte development and platelet production
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
Parkinson's disease (PD)
GWAS
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
81 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CCNI
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PRKN
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SPDYE4
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
39 interacting genes:
-
ACTA1
ALDH1A2
APC
APP
AREL1
BIRC2
BIRC3
BIRC6
BIRC7
CAD
CCAR2
CDK1
CDK5
CSN1S1
CSN2
DIABLO
EEF1A1
EIF4G1
HSD17B10
IMMT
MAPK11
MAPK12
MAPK13
MAPK14
MAPK3
MUL1
PAG1
PDXDC1
PEA15
TRIM28
TUBA1A
TUBB
TUBB6
TUBB7P
USP7
VIM
VPS4B
XIAP
Entrez ID
1020
27429
HPRD ID
00449
05919
Ensembl ID
ENSG00000164885
ENSG00000115317
Uniprot IDs
A0A090N7W4
A0A0S2Z355
Q00535
A0A384MDW9
O43464
PDB IDs
1H4L
1LFR
1UNG
1UNH
1UNL
3O0G
4AU8
1LCY
2PZD
5FHT
5M3N
5M3O
5TNY
5TNZ
5TO0
5TO1
5WYN
Enriched GO Terms of Interacting Partners
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