CDK5 and MEOX2

Data Source:
BioGRID (two hybrid)

		CDK5	MEOX2
Description		cyclin dependent kinase 5	mesenchyme homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Lamellipodium Cell Junction Filopodium Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Perikaryon Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse	Chromatin Nucleus Cytoplasm Nuclear Speck
	Molecular Function	P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ErbB-2 Class Receptor Binding Protein Binding ATP Binding Microtubule Binding Kinase Activity Protein Kinase Binding Acetylcholine Receptor Activator Activity ErbB-3 Class Receptor Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Hsp90 Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Neuron Migration Synaptic Transmission, Dopaminergic Protein Phosphorylation Intracellular Protein Transport Nucleocytoplasmic Transport Mitochondrion Organization Cell-matrix Adhesion Chemical Synaptic Transmission Axonogenesis Synapse Assembly Skeletal Muscle Tissue Development Motor Neuron Axon Guidance Visual Learning Response To Wounding Schwann Cell Development Synaptic Vesicle Exocytosis Regulation Of Macroautophagy Phosphorylation Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cerebellar Cortex Formation Hippocampus Development Layer Formation In Cerebral Cortex Central Nervous System Neuron Development Corpus Callosum Development Neuron Differentiation Regulation Of Cell Migration Negative Regulation Of Axon Extension Cortical Actin Cytoskeleton Organization Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Synaptic Plasticity Positive Regulation Of Protein Binding Receptor Catabolic Process Positive Regulation Of Glial Cell Apoptotic Process Synaptic Transmission, Glutamatergic Protein Localization To Synapse Serine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Autophosphorylation Negative Regulation Of Protein Export From Nucleus Behavioral Response To Cocaine Regulation Of Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Axon Extension Oligodendrocyte Differentiation Dendrite Morphogenesis Cell Division Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Morphogenesis Calcium Ion Import Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Synapse Pruning Regulation Of Neurotransmitter Receptor Activity Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Neuron Death Positive Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Localization To Plasma Membrane Regulation Of Synaptic Vesicle Recycling Cellular Response To Amyloid-beta Positive Regulation Of Actin Cytoskeleton Reorganization	Angiogenesis Somite Specification Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Skeletal Muscle Tissue Development Blood Circulation Positive Regulation Of Transcription By RNA Polymerase II Roof Of Mouth Development Limb Development Somite Development Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		DARPP-32 events CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription Activated NTRK2 signals through CDK5 Factors involved in megakaryocyte development and platelet production
Drugs		Indirubin-3'-monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS		Eyebrow thickness ( 26926045) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)	Adolescent idiopathic scoliosis ( 31417091) Blood trace element (Zn levels) ( 23720494) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) HOMA-B (corrected for HOMA-IR) ( 30369944) Kidney function decline traits ( 25493955) Resting-state electroencephalogram vigilance ( 29703947) Sweet taste preference ( 32572145) Total intracranial volume ( 31530798) Triglyceride levels ( 32203549)
Interacting Genes		81 interacting genes: AATK ABL1 ACTN1 ALAS1 AMPH APP BAG6 CABLES1 CABLES2 CCND2 CCND3 CCNG1 CCNI CDC25A CDC25B CDC25C CDC37 CDK16 CDK5R1 CDK5R2 CDK5RAP1 CDK5RAP2 CDKN1B CHN1 CSNK1D DAB1 DCX DNM1 ERBB3 EZR FSD1 FYN FZR1 GAK GRIN2A GSK3B H1-0 H1-1 H1-5 HTRA2 KIF26B LMTK2 MAP2K1 MAPK10 MAPT MAST1 MBP MEF2A MEOX2 MIR9-1HG NDEL1 NEDD4 NEDD4L NES PAK1 PCNA PIKFYVE PIP5K1C PPARG PPP1R1B PPP1R2 PRKN PSEN1 PTPN2 PURA RB1 RNF32 RPL34 SET SPDYA SPDYE4 SRC STX1A STXBP1 SYN1 SYNJ1 TLN1 TP53 TRIM59 WASF1 YBX3	686 interacting genes: - ABI2 ACBD4 ACOT12 ACSS1 ACTN4 ADAMTS12 ADGRF4 AGPAT1 AHCYL1 AHNAK AHSA2P AKT2 ALOX5 ALPP AMMECR1 AMOT ANKRD1 ANKRD12 ANKS1A ANP32B AP3M2 ARF6 ARHGEF7 ARIH2 ARL15 ARNT2 ARNTL2 ASB10 ATG12 ATG2A ATG5 ATG9A ATP5F1C ATP6V0D2 ATP6V1C2 ATPSCKMT ATXN1L AXIN1 B4GALT2 BANP BCL2L15 BEX1 BMP5 BNIP2 BOD1L2 BOLA2 BOLA2B BTBD3 BTK BTN1A1 BUD31 BYSL C10orf120 C10orf88 C11orf68 C1orf109 C1orf174 C1orf50 C2orf76 C9orf64 CACNA1S CAMK2B CAPRIN2 CARD9 CASP14 CBX2 CCDC102B CCDC103 CCDC13 CCDC196 CCDC6 CCL19 CCNC CCNYL1 CDC34 CDC7 CDCA7L CDH9 CDK3 CDK5 CDKN1A CDKN2D CEP57L1 CFAP206 CHD2 CHIC2 CHRD CHRNB4 CHRNG CHST15 CIAO1 CIAPIN1 CIB3 CINP CKS1B CLIC1 CLIP4 CLP1 CLVS2 CMTM5 CNTNAP2 COG7 COL9A2 COMP COX7A2 CPNE2 CPNE6 CPNE7 CPSF4 CRCT1 CSDC2 CSF2 CSH2 CSNK2A1 CT55 CTNNBL1 CUTC CXCL1 CXCL5 CXorf38 CXXC1 CYB5R2 CYCS CYP4F12 CYSRT1 DCX DEF8 DEFA5 DEPDC5 DESI1 DGCR6 DGCR8 DHPS DIRAS3 DMRT3 DNAAF11 DNAJC17 DNAJC22 DNMT3A DOCK8 DPF2 DPH3 DPM1 DRG1 DSCR8 DUS1L DYNC2I2 DYNLL2 DYNLT5 E2F8 EDF1 EFEMP1 EFEMP2 EFNA3 EIF1AD EIF3G EIF4A3 EIF5A EIF6 EMC7 EMD EME2 EPM2AIP1 ERF ESM1 ESR2 ESRRG ETV4 EXOSC5 FAAP20 FAM126A FAM13C FAM219B FAM221A FAM3A FAM53B FAM53C FAM71E2 FAM74A4 FANCC FANCG FBF1 FBLN1 FBLN5 FBXO39 FBXO44 FDX2 FGA FKBP6 FOSL2 FOXR1 FTL FUCA2 FUT11 FYN GABRB3 GAGE1 GCM2 GINS3 GJC1 GLO1 GMCL2 GMPR2 GNG11 GNG13 GOLGA8DP GOLGA8EP GOLGA8F GPANK1 GPATCH2L GPKOW GPSM3 GRIPAP1 GRN GSDMD GTPBP3 GUCD1 H1-7 HAT1 HDAC7 HDHD2 HELLS HEXIM2 HGF HK3 HLA-A HLA-DPB1 HMBOX1 HMGB3 HNRNPC HNRNPD HOOK1 HOOK3 HORMAD1 HOXB5 HOXC8 HP1BP3 HSD3B7 HSPA2 HTR1E IFIT2 IFNA14 IFNA6 IGF2BP3 IGFN1 IKZF1 IL1A ILF2 INPP1 INPP5J INSRR INTS10 IP6K2 IP6K3 IQGAP1 IRX6 ITGB3BP ITM2A JAM3 JPH1 KANK2 KAT5 KATNAL1 KBTBD7 KCNIP4 KCTD7 KCTD9 KDM6A KDM8 KIF5B KIF5C KIZ KLC4 KLHL32 KLHL38 KPRP KRT80 KRT81 KRT83 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KRTCAP3 KTN1 LAMTOR5 LARP1B LAT LCE1B LCE1D LCE1E LCE2A LCE4A LCN15 LEMD1 LIN37 LIPF LMO1 LNX1 LRRC18 LRRC27 LRRC52 LSM2 LUC7L2 LY6G6D MAB21L2 MACO1 MAGED1 MALSU1 MAPKBP1 MAPRE1 MAPRE3 MBD3 MCM7 MDFI METAP1 METTL17 METTL21A MFF MICOS10-NBL1 MID2 MKRN3 MLF1 MLLT6 MLX MMP25 MMP3 MOAP1 MOBP MORF4L1 MORF4L2 MORN3 MOS MPP1 MRFAP1L1 MSI2 MT-CO1 MT-ND1 MT1DP MTMR10 MVP MYBPC1 MYL7 MYO5B NAA10 NAA60 NALCN NBL1 NCALD NCK2 NCS1 NDUFA11 NDUFB2 NECTIN2 NEK6 NELL1 NFKBID NFYB NLGN3 NME7 NOL4 NOP10 NPIPB5 NR1D2 NSF NTAN1 NTF3 NTN4 ODAD4 ODF1 ODF2 ODF2L ODF4 OIT3 OLFM1 OLFM3 OR5K2 OR6B1 OSBPL1A OSGIN1 OSTF1 P4HA3 PACSIN2 PAGE2 PAGE5 PAK1IP1 PAM16 PARP3 PARVG PAX1 PAX3 PCDH9 PCSK5 PDE4C PDHA2 PDP1 PDS5A PELO PGBD1 PHF1 PICK1 PIN1 PKIG PLAC8 PLCB4 PLCD4 PMM2 PMS2 PNKP PNLIPRP1 POLR1A POLR1C POLR3GL POM121C POMT1 PPP1CB PPP1R18 PRAP1 PRKAB2 PRKAG1 PRKCI PRKG1 PRKN PRL PRMT3 PRPF18 PRPF31 PRR19 PSMB10 PSMB8 PSMC1 PSMD14 PSMD9 PSME3 PTGER3 PWWP3A PXT1 RAB11B RAB2B RAB41 RAB6B RAD51B RAD51D RAD52 RAP1GAP2 RARB RASAL2 RBM10 RBM5 RBPJL RCHY1 RECK RELA RFTN2 RFX3 RGS5 RHOJ RIMS3 RIPPLY1 RMND5A RND2 RNF25 RNF40 RNF41 RNF6 RPL15 RPL23 RPP40 RPS4Y1 RRP8 RUNX1T1 RWDD2B SAE1 SAMD4A SAMM50 SAT1 SATB1 SCAF1 SCARF1 SCG5 SCIMP SCNM1 SCRN2 SDCBP SEC14L4 SEC63 SELENOP SET SFTPB SH2D1B SH2D4A SHFL SHISA3 SIRPB1 SKP1 SLC22A23 SLC23A1 SLC24A5 SLC25A17 SLC25A31 SLC27A5 SLC48A1 SLC66A1L SLC9A8 SLIT1 SMAD3 SMARCE1 SMG6 SMYD1 SNRPF SPANXN2 SPANXN3 SPATA1 SPEG SPON1 SPP1 SPRED1 SPRY1 SPRY2 SPRY3 SPTY2D1 SRSF11 SSX3 STAC STC1 STK11IP STK16 STRA8 STX11 STX16 STX6 STXBP1 SUFU SUSD4 SYNE2 SYT17 TAF1B TASOR2 TBC1D21 TBCEL TBL2 TBRG4 TBX6 TCEA2 TCEANC TCL6 TDO2 TEX14 TEX47 TGFB1 THRA TICAM2 TJAP1 TMEM100 TMEM14B TMEM266 TMPRSS11E TNPO3 TP53BP1 TPTE TRAF5 TRAF6 TRAPPC2L TRARG1 TRIM17 TRIM41 TRIM42 TRIM45 TRIM50 TRIML2 TRIP10 TRMT112 TRMT2A TSGA10IP TSPAN7 TSPO TSR2 TSSK1B TSTD2 TTC39B TTC9C TTLL10 TULP2 TXLNA TXLNB TXN2 TXNL4B U2AF1 U2AF1L5 UBA2 UBE2D1 UBE2K UBE3A UBL4A UBL4B UBXN2B UBXN8 UNC45A UPP2 USE1 USP20 USP32 UTP14C UTP23 UTP25 VAC14 VASN VBP1 VCX2 VDR VEZF1 VIP VMP1 VPS26C VWA5A VWC2L VWCE WDR37 WDR5 WFDC13 WFDC5 WFDC6 WFDC9 XPA XRCC2 YJU2 ZBED4 ZBED8 ZBTB16 ZBTB2 ZCWPW1 ZFP42 ZKSCAN3 ZKSCAN4 ZMAT2 ZMYND8 ZNF124 ZNF202 ZNF23 ZNF248 ZNF250 ZNF276 ZNF329 ZNF330 ZNF404 ZNF410 ZNF417 ZNF483 ZNF490 ZNF512B ZNF556 ZNF564 ZNF572 ZNF574 ZNF587 ZNF648 ZNF688 ZNF69 ZNF695 ZNF772 ZNF92
Entrez ID		1020	4223
HPRD ID		00449	02760
Ensembl ID		ENSG00000164885	ENSG00000106511
Uniprot IDs		A0A090N7W4 A0A0S2Z355 Q00535	P50222
PDB IDs		1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8
Enriched GO Terms of Interacting Partners?
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